Clinical Manifestations, Diagnosis, and Treatment of Sarcoidosis
Identifieur interne : 000953 ( Main/Exploration ); précédent : 000952; suivant : 000954Clinical Manifestations, Diagnosis, and Treatment of Sarcoidosis
Auteurs : Patompong Ungprasert [Thaïlande] ; Jay H. Ryu [États-Unis] ; Eric L. Matteson [États-Unis]Source :
- Mayo Clinic Proceedings: Innovations, Quality & Outcomes [ 2542-4548 ] ; 2019.
Abstract
The focus of this review is current knowledge about the epidemiology, clinical manifestations, diagnosis, and treatment of both pulmonary sarcoidosis and extrapulmonary sarcoidosis. Although intrathoracic involvement is the hallmark of the disease, present in over 90% of patients, sarcoidosis can affect virtually any organ. Clinical presentations of sarcoidosis are diverse, ranging from asymptomatic, incidental findings to organ failure. Diagnosis requires the presence of noncaseating granuloma and compatible presentations after exclusion of other identifiable causes. Spontaneous remission is frequent, so treatment is not always indicated unless the disease is symptomatic or causes progressive organ damage/dysfunction. Glucocorticoids are the cornerstone of treatment of sarcoidosis even though evidence from randomized controlled studies is lacking. Glucocorticoid-sparing agents and biologic agents are often used as second- and third-line therapy for patients who do not respond to glucocorticoids or experience serious adverse effects.
Url:
DOI: 10.1016/j.mayocpiqo.2019.04.006
PubMed: 31485575
PubMed Central: 6713839
Affiliations:
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Ryu</name><affiliation wicri:level="2"><nlm:aff id="aff2">Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Matteson, Eric L" sort="Matteson, Eric L" uniqKey="Matteson E" first="Eric L." last="Matteson">Eric L. Matteson</name><affiliation wicri:level="2"><nlm:aff id="aff3">Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff4">Division of Epidemiology, Department of Health Sciences Research (E.L.M.), Mayo Clinic, Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Division of Epidemiology, Department of Health Sciences Research (E.L.M.), Mayo Clinic, Rochester</wicri:cityArea></affiliation></author></analytic><series><title level="j">Mayo Clinic Proceedings: Innovations, Quality & Outcomes</title><idno type="eISSN">2542-4548</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The focus of this review is current knowledge about the epidemiology, clinical manifestations, diagnosis, and treatment of both pulmonary sarcoidosis and extrapulmonary sarcoidosis. Although intrathoracic involvement is the hallmark of the disease, present in over 90% of patients, sarcoidosis can affect virtually any organ. Clinical presentations of sarcoidosis are diverse, ranging from asymptomatic, incidental findings to organ failure. Diagnosis requires the presence of noncaseating granuloma and compatible presentations after exclusion of other identifiable causes. Spontaneous remission is frequent, so treatment is not always indicated unless the disease is symptomatic or causes progressive organ damage/dysfunction. Glucocorticoids are the cornerstone of treatment of sarcoidosis even though evidence from randomized controlled studies is lacking. 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Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nagai, S" uniqKey="Nagai S">S. Nagai</name></author><author><name sortKey="Yokomatsu, T" uniqKey="Yokomatsu T">T. Yokomatsu</name></author><author><name sortKey="Tanizawa, K" uniqKey="Tanizawa K">K. Tanizawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krause, M L" uniqKey="Krause M">M.L. Krause</name></author><author><name sortKey="Cooper, L T" uniqKey="Cooper L">L.T. Cooper</name></author><author><name sortKey="Chareonthaitawee, P" uniqKey="Chareonthaitawee P">P. Chareonthaitawee</name></author><author><name sortKey="Amin, S" uniqKey="Amin S">S. Amin</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Thaïlande</li><li>États-Unis</li></country><region><li>Minnesota</li></region></list><tree><country name="Thaïlande"><noRegion><name sortKey="Ungprasert, Patompong" sort="Ungprasert, Patompong" uniqKey="Ungprasert P" first="Patompong" last="Ungprasert">Patompong Ungprasert</name></noRegion></country><country name="États-Unis"><region name="Minnesota"><name sortKey="Ryu, Jay H" sort="Ryu, Jay H" uniqKey="Ryu J" first="Jay H." last="Ryu">Jay H. Ryu</name></region><name sortKey="Matteson, Eric L" sort="Matteson, Eric L" uniqKey="Matteson E" first="Eric L." last="Matteson">Eric L. Matteson</name><name sortKey="Matteson, Eric L" sort="Matteson, Eric L" uniqKey="Matteson E" first="Eric L." last="Matteson">Eric L. Matteson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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